Guardians of the Galaxy is a fictional superhero team appearing in comic books published by Marvel Comics. The term may refer to:
- Guardians of the Galaxy (1969 team), the original 31st-century team from an alternative time-line of the Marvel Universe (Earth-691)
- Guardians of the Galaxy (2008 team), the modern version of the team formed in the aftermath of Annihilation: Conquest
- Guardians of the Galaxy (film), the 2014 film based on the 2008 comic book version
- Guardians of the Galaxy (soundtrack), the soundtrack for the film
See also
- List of Guardians of the Galaxy members
- Guardians of the Universe, an unrelated race from DC Comics